||In our data-driven world, large amounts of data are collected in all kinds of environments. That is why data analysis rises in importance. How different variables influence each other is a significant part of knowledge discovery and allows strategic decisions based on this knowledge. Therefore, high-quality dependency estimation should be accessible to a variety of people. Many dependency estimation algorithms are difficult to use in a real-world setting. In addition, most of these dependency estimation algorithms need large data sets to return a good estimation. In practice, gathering this amount of data may be costly, especially when the data is collected in experiments with high costs for materials or infrastructure. I will do a comparison of different state-of-the-art dependency estimation algorithms. A list of 14 different criteria I but together, will be used to determine how promising the algorithm is. This study focuses especially on data efficiency and uncertainty of the dependency estimation algorithms. An algorithm with a high data efficiency can give a good estimation with a small amount of data. A degree of uncertainty helps to interpret the result of the estimator. This allows better decision-making in practice. The comparison includes a theoretical analysis and conducting different experiments with dependency estimation algorithms that performed well in the theoretical analysis.